Overview
| Uniprot ID | P58304 |
|---|
| Protein Name | Visual system homeobox 2 |
|---|
| Gene Name | VSX2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 4 |
****MTGKAGEALSK |
Function
Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). May play a role in specification of V2a interneurons during spinal cord development (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076)
Protein Sequence
10
MTGKAGEALS
20
KPKSETVAKS
30
TSGGAPARCT
40
GFGIQEILGL
50
NKEPPSSHPR
60
AALDGLAPGH
70
LLAARSVLSP
80
AGVGGMGLLG
90
PGGLPGFYTQ
100
PTFLEVLSDP
110
QSVHLQPLGR
120
ASGPLDTSQT
130
ASSDSEDVSS
140
SDRKMSKSAL
150
NQTKKRKKRR
160
HRTIFTSYQL
170
EELEKAFNEA
180
HYPDVYAREM
190
LAMKTELPED
200
RIQVWFQNRR
210
AKWRKREKCW
220
GRSSVMAEYG
230
LYGAMVRHSI
240
PLPESILKSA
250
KDGIMDSCAP
260
WLLGMHKKSL
270
EAAAESGRKP
280
EGERQALPKL
290
DKMEQDERGP
300
DAQAAISQEE
310
LRENSIAVLR
320
AKAQEHSTKV
330
LGTVSGPDSL
340
ARSTEKPEEE
350
EAMDEDRPAE
360
RLSPPQLEDM
A
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000977 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0007601 |
visual perception |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.