Search Results
Overview
| Uniprot ID | P58546 |
|---|---|
| Protein Name | Myotrophin |
| Gene Name | MTPN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | EVKDYVAKGEDVNRT |
| 4 | ****MCDKEFMWALK |
| 85 | EGHVSCVKLLLSKGA |
| 90 | CVKLLLSKGADKTVK |
| 97 | KGADKTVKGPDGLTA |
Function
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0010557 | positive regulation of macromolecule biosynthetic process |
| Biological Process | GO:0051247 | positive regulation of protein metabolic process |
| Biological Process | GO:2000812 | regulation of barbed-end actin filament capping |
| Biological Process | GO:0008361 | regulation of cell size |
| Biological Process | GO:0016202 | regulation of striated muscle tissue development |
| Biological Process | GO:0006417 | regulation of translation |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.