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Overview

Uniprot IDP59215
Protein NameGuanine nucleotide-binding protein G(o) subunit alpha
Gene NameGnao1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
105 KERKADSKMVCDVVS
181 DILRTRVKTTGIVET
193 VETHFTFKNLHFRLF
24 KAIEKNLKEDGISAA
272 IILFLNKKDLFGEKI
32 EDGISAAKDVKLLLL
46 LGAGESGKSTIVKQM
54 STIVKQMKIIHEDGF
67 GFSGEDVKQYKPVVY
98 LGVEYGDKERKADSK

Function

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (By similarity). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity)

Protein Sequence

10 MGCTLSAEER 20 AALERSKAIE 30 KNLKEDGISA 40 AKDVKLLLLG 50 AGESGKSTIV 60 KQMKIIHEDG 70 FSGEDVKQYK 80 PVVYSNTIQS 90 LAAIVRAMDT 100 LGVEYGDKER 110 KADSKMVCDV 120 VSRMEDTEPF 130 SAELLSAMMR 140 LWGDSGIQEC 150 FNRSREYQLN 160 DSAKYYLDSL 170 DRIGAADYQP 180 TEQDILRTRV 190 KTTGIVETHF 200 TFKNLHFRLF 210 DVGGQRSERK 220 KWIHCFEDVT 230 AIIFCVALSG 240 YDQVLHEDET 250 TNRMHESLML 260 FDSICNNKFF 270 IDTSIILFLN 280 KKDLFGEKIK 290 KSPLTICFPE 300 YPGSNTYEDA 310 AAYIQTQFES 320 KNRSPNKEIY 330 CHMTCATDTN 340 NIQVVFDAVT 350 DIIIANNLRG CGLY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044297 cell body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005834 heterotrimeric G-protein complex
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0098688 parallel fiber to Purkinje cell synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0051430 corticotropin-releasing hormone receptor 1 binding
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0031821 G protein-coupled serotonin receptor binding
Molecular Function GO:0031683 G-protein beta/gamma-subunit complex binding
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0032794 GTPase activating protein binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0031852 mu-type opioid receptor binding
Molecular Function GO:0099104 potassium channel activator activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0030900 forebrain development
Biological Process GO:0007212 G protein-coupled dopamine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0051926 negative regulation of calcium ion transport
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0031175 neuron projection development
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0034097 response to cytokine
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:1904014 response to serotonin
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.