Search Results
Overview
| Uniprot ID | P59649 |
|---|---|
| Protein Name | FXYD domain-containing ion transport regulator 7 |
| Gene Name | Fxyd7 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 67 | SPTCKSCKSELPSSA |
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (By similarity). Increases the apparent affinity for intracellular Na(+) (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:0043269 | regulation of monoatomic ion transport |
| Biological Process | GO:0006814 | sodium ion transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.