Overview
| Uniprot ID | P59768 |
|---|
| Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 |
|---|
| Gene Name | GNG2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 32 |
IDRIKVSKAAADLMA |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625, PubMed:39103320). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625, PubMed:39103320)
Protein Sequence
10
MASNNTASIA
20
QARKLVEQLK
30
MEANIDRIKV
40
SKAAADLMAY
50
CEAHAKEDPL
60
LTPVPASENP
70
FREKKFFCAI
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005834 |
heterotrimeric G-protein complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0031681 |
G-protein beta-subunit binding |
| Biological Process |
GO:0007191 |
adenylate cyclase-activating dopamine receptor signaling pathway |
| Biological Process |
GO:0071870 |
cellular response to catecholamine stimulus |
| Biological Process |
GO:0071380 |
cellular response to prostaglandin E stimulus |
| Biological Process |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.