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Overview

Uniprot IDP59923
Protein NameZinc finger protein 445
Gene NameZNF445
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
707 QRIHTGEKPYQCSDC
728 RSAFIVHKKKHAMKR

Function

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440)

Protein Sequence

10 MPPGRWHAAY 20 PAQAQSSRER 30 GRLQTVKKEE 40 EDESYTPVQA 50 ARPQTLNRPG 60 QELFRQLFRQ 70 LRYHESSGPL 80 ETLSRLRELC 90 RWWLRPDVLS 100 KAQILELLVL 110 EQFLSILPGE 120 LRVWVQLHNP 130 ESGEEAVALL 140 EELQRDLDGT 150 SWRDPGPAQS 160 PDVHWMGTGA 170 LRSAQIWSLA 180 SPLRSSSALG 190 DHLEPPYEIE 200 ARDFLAGQSD 210 TPAAQMPALF 220 PREGCPGDQV 230 TPTRSLTAQL 240 QETMTFKDVE 250 VTFSQDEWGW 260 LDSAQRNLYR 270 DVMLENYRNM 280 ASLVGPFTKP 290 ALISWLEARE 300 PWGLNMQAAQ 310 PKGNPVAAPT 320 GDDLQSKTNK 330 FILNQEPLEE 340 AETLAVSSGC 350 PATSVSEGIG 360 LRESFQQKSR 370 QKDQCENPIQ 380 VRVKKEETNF 390 SHRTGKDSEV 400 SGSNSLDLKH 410 VTYLRVSGRK 420 ESLKHGCGKH 430 FRMSSHHYDY 440 KKYGKGLRHM 450 IGGFSLHQRI 460 HSGLKGNKKD 470 VCGKDFSLSS 480 HHQRGQSLHT 490 VGVSFKCSDC 500 GRTFSHSSHL 510 AYHQRLHTQE 520 KAFKCRVCGK 530 AFRWSSNCAR 540 HEKIHTGVKP 550 YKCDLCEKAF 560 RRLSAYRLHR 570 ETHAKKKFLE 580 LNQYRAALTY 590 SSGFDHHLGD 600 QSGEKLFDCS 610 QCRKSFHCKS 620 YVLEHQRIHT 630 QEKPYKCTKC 640 RKTFRWRSNF 650 TRHMRLHEEE 660 KFYKQDECRE 670 GFRQSPDCSQ 680 PQGAPAVEKT 690 FLCQQCGKTF 700 TRKKTLVDHQ 710 RIHTGEKPYQ 720 CSDCGKDFAY 730 RSAFIVHKKK 740 HAMKRKPEGG 750 PSFSQDTVFQ 760 VPQSSHSKEE 770 PYKCSQCGKA 780 FRNHSFLLIH 790 QRVHTGEKPY 800 KCRECGKAFR 810 WSSNLYRHQR 820 IHSLQKQYDC 830 HESEKTPNVE 840 PKILTGEKRF 850 WCQECGKTFT 860 RKRTLLDHKG 870 IHSGEKRYKC 880 NLCGKSYDRN 890 YRLVNHQRIH 900 STERPFKCQW 910 CGKEFIGRHT 920 LSSHQRKHTR 930 AAQAERSPPA 940 RSSSQDTKLR 950 LQKLKPSEEM 960 PLEDCKEACS 970 QSSRLTGLQD 980 ISIGKKCHKC 990 SICGKTFNKS 1000 SQLISHKRFH 1010 TRERPFKCSK 1020 CGKTFRWSSN 1030 LARHMKNHIR D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0010385 double-stranded methylated DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0044726 epigenetic programing of female pronucleus
Biological Process GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.