Overview
| Uniprot ID | P59999 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 4 |
|---|
| Gene Name | Arpc4 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 128 |
FHTEQMYKHKLVDFV |
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MTATLRPYLS
20
AVRATLQAAL
30
CLENFSSQVV
40
ERHNKPEVEV
50
RSSKELLLQP
60
VTISRNEKEK
70
VLIEGSINSV
80
RVSIAVKQAD
90
EIEKILCHKF
100
MRFMMMRAEN
110
FFILRRKPVE
120
GYDISFLITN
130
FHTEQMYKHK
140
LVDFVIHFME
150
EIDKEISEMK
160
LSVNARARIV
AEEFLKNF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0035861 |
site of double-strand break |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.