Search Results
Overview
| Uniprot ID | P60201 |
|---|---|
| Protein Name | Myelin proteolipid protein |
| Gene Name | PLP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | RQIFGDYKTTICGKG |
| 111 | YKTTICGKGLSATVT |
| 122 | ATVTGGQKGRGSRGQ |
Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin
Protein Sequence
10
MGLLECCARC
20
LVGAPFASLV
30
ATGLCFFGVA
40
LFCGCGHEAL
50
TGTEKLIETY
60
FSKNYQDYEY
70
LINVIHAFQY
80
VIYGTASFFF
90
LYGALLLAEG
100
FYTTGAVRQI
110
FGDYKTTICG
120
KGLSATVTGG
130
QKGRGSRGQH
140
QAHSLERVCH
150
CLGKWLGHPD
160
KFVGITYALT
170
VVWLLVFACS
180
AVPVYIYFNT
190
WTTCQSIAFP
200
SKTSASIGSL
210
CADARMYGVL
220
PWNAFPGKVC
230
GSNLLSICKT
240
AEFQMTFHLF
250
IAAFVGAAAT
260
LVSLLTFMIA
270
ATYNFAVLKL
MGRGTKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019911 | structural constituent of myelin sheath |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0008366 | axon ensheathment |
| Biological Process | GO:0022010 | central nervous system myelination |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.