Search Results
Overview
| Uniprot ID | P60203 |
|---|---|
| Protein Name | Myelin proteolipid protein |
| Gene Name | Plp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | RQIFGDYKTTICGKG |
| 111 | YKTTICGKGLSATVT |
| 122 | ATVTGGQKGRGSRGQ |
| 144 | RVCHCLGKWLGHPDK |
Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin
Protein Sequence
10
MGLLECCARC
20
LVGAPFASLV
30
ATGLCFFGVA
40
LFCGCGHEAL
50
TGTEKLIETY
60
FSKNYQDYEY
70
LINVIHAFQY
80
VIYGTASFFF
90
LYGALLLAEG
100
FYTTGAVRQI
110
FGDYKTTICG
120
KGLSATVTGG
130
QKGRGSRGQH
140
QAHSLERVCH
150
CLGKWLGHPD
160
KFVGITYALT
170
VVWLLVFACS
180
AVPVYIYFNT
190
WTTCQSIAFP
200
SKTSASIGSL
210
CADARMYGVL
220
PWNAFPGKVC
230
GSNLLSICKT
240
AEFQMTFHLF
250
IAAFVGAAAT
260
LVSLLTFMIA
270
ATYNFAVLKL
MGRGTKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034683 | integrin alphav-beta3 complex |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0019911 | structural constituent of myelin sheath |
| Biological Process | GO:0098990 | AMPA selective glutamate receptor signaling pathway |
| Biological Process | GO:0014002 | astrocyte development |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0008366 | axon ensheathment |
| Biological Process | GO:0048469 | cell maturation |
| Biological Process | GO:0022010 | central nervous system myelination |
| Biological Process | GO:0010001 | glial cell differentiation |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0042759 | long-chain fatty acid biosynthetic process |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:1904427 | positive regulation of calcium ion transmembrane transport |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.