Search Results
Overview
| Uniprot ID | P60335 |
|---|---|
| Protein Name | Poly(rC)-binding protein 1 |
| Gene Name | Pcbp1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | QCGSLIGKGGCKIKE |
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713)
Protein Sequence
10
MDAGVTESGL
20
NVTLTIRLLM
30
HGKEVGSIIG
40
KKGESVKRIR
50
EESGARINIS
60
EGNCPERIIT
70
LTGPTNAIFK
80
AFAMIIDKLE
90
EDINSSMTNS
100
TAASRPPVTL
110
RLVVPATQCG
120
SLIGKGGCKI
130
KEIRESTGAQ
140
VQVAGDMLPN
150
STERAITIAG
160
VPQSVTECVK
170
QICLVMLETL
180
SQSPQGRVMT
190
IPYQPMPASS
200
PVICAGGQDR
210
CSDAAGYPHA
220
THDLEGPPLD
230
AYSIQGQHTI
240
SPLDLAKLNQ
250
VARQQSHFAM
260
MHGGTGFAGI
270
DSSSPEVKGY
280
WASLDASTQT
290
THELTIPNNL
300
IGCIIGRQGA
310
NINEIRQMSG
320
AQIKIANPVE
330
GSSGRQVTIT
340
GSAASISLAQ
350
YLINARLSSE
KGMGCS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0039694 | viral RNA genome replication |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0034986 | iron chaperone activity |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0098847 | sequence-specific single stranded DNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0008494 | translation activator activity |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.