Search Results
Overview
| Uniprot ID | P60710 |
|---|---|
| Protein Name | Actin, cytoplasmic 1 |
| Gene Name | Actb |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | TEAPLNPKANREKMT |
| 328 | APSTMKIKIIAPPER |
| 50 | VMVGMGQKDSYVGDE |
| 61 | VGDEAQSKRGILTLK |
Function
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0097433 | dense body |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0098871 | postsynaptic actin cytoskeleton |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0030235 | nitric-oxide synthase regulator activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton |
| Molecular Function | GO:0030957 | Tat protein binding |
| Molecular Function | GO:0141108 | transporter regulator activity |
| Biological Process | GO:0034333 | adherens junction assembly |
| Biological Process | GO:0045176 | apical protein localization |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0072749 | cellular response to cytochalasin B |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0001738 | morphogenesis of a polarized epithelium |
| Biological Process | GO:0045596 | negative regulation of cell differentiation |
| Biological Process | GO:0045597 | positive regulation of cell differentiation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0045663 | positive regulation of myoblast differentiation |
| Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
| Biological Process | GO:0045582 | positive regulation of T cell differentiation |
| Biological Process | GO:0071896 | protein localization to adherens junction |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000779 | regulation of double-strand break repair |
| Biological Process | GO:0070316 | regulation of G0 to G1 transition |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:0051621 | regulation of norepinephrine uptake |
| Biological Process | GO:2000819 | regulation of nucleotide-excision repair |
| Biological Process | GO:1903076 | regulation of protein localization to plasma membrane |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0150111 | regulation of transepithelial transport |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.