Search Results
Overview
| Uniprot ID | P60843 |
|---|---|
| Protein Name | Eukaryotic initiation factor 4A-I |
| Gene Name | Eif4a1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | NVRAEVQKLQMEAPH |
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity)
Protein Sequence
10
MSASQDSRSR
20
DNGPDGMEPE
30
GVIESNWNEI
40
VDSFDDMNLS
50
ESLLRGIYAY
60
GFEKPSAIQQ
70
RAILPCIKGY
80
DVIAQAQSGT
90
GKTATFAISI
100
LQQIELDLKA
110
TQALVLAPTR
120
ELAQQIQKVV
130
MALGDYMGAS
140
CHACIGGTNV
150
RAEVQKLQME
160
APHIIVGTPG
170
RVFDMLNRRY
180
LSPKYIKMFV
190
LDEADEMLSR
200
GFKDQIYDIF
210
QKLNSNTQVV
220
LLSATMPSDV
230
LEVTKKFMRD
240
PIRILVKKEE
250
LTLEGIRQFY
260
INVEREEWKL
270
DTLCDLYETL
280
TITQAVIFIN
290
TRRKVDWLTE
300
KMHARDFTVS
310
AMHGDMDQKE
320
RDVIMREFRS
330
GSSRVLITTD
340
LLARGIDVQQ
350
VSLVINYDLP
360
TNRENYIHRI
370
GRGGRFGRKG
380
VAINMVTEED
390
KRTLRDIETF
400
YNTSIEEMPL
NVADLI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0097165 | nuclear stress granule |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:0002183 | cytoplasmic translational initiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006413 | translational initiation |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.