Search Results
Overview
| Uniprot ID | P60880 |
|---|---|
| Protein Name | Synaptosomal-associated protein 25 |
| Gene Name | SNAP25 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 184 | QIDRIMEKADSNKTR |
| 40 | LQLVEESKDAGIRTL |
Function
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells
Protein Sequence
10
MAEDADMRNE
20
LEEMQRRADQ
30
LADESLESTR
40
RMLQLVEESK
50
DAGIRTLVML
60
DEQGEQLERI
70
EEGMDQINKD
80
MKEAEKNLTD
90
LGKFCGLCVC
100
PCNKLKSSDA
110
YKKAWGNNQD
120
GVVASQPARV
130
VDEREQMAIS
140
GGFIRRVTND
150
ARENEMDENL
160
EQVSGIIGNL
170
RHMALDMGNE
180
IDTQNRQIDR
190
IMEKADSNKT
200
RIDEANQRAT
KMLGSG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0097470 | ribbon synapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0035579 | specific granule membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0005249 | voltage-gated potassium channel activity |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0001504 | neurotransmitter uptake |
| Biological Process | GO:0099525 | presynaptic dense core vesicle exocytosis |
| Biological Process | GO:0050796 | regulation of insulin secretion |
| Biological Process | GO:0010975 | regulation of neuron projection development |
| Biological Process | GO:0016081 | synaptic vesicle docking |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane |
| Biological Process | GO:0016082 | synaptic vesicle priming |
| Biological Process | GO:0006906 | vesicle fusion |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.