Search Results
Overview
| Uniprot ID | P60881 |
|---|---|
| Protein Name | Synaptosomal-associated protein 25 |
| Gene Name | Snap25 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | KSSDAYKKAWGNNQD |
| 184 | QIDRIMEKADSNKTR |
| 40 | LQLVEESKDAGIRTL |
| 69 | EGMDQINKDMKEAEK |
| 94 | LCVCPCNKLKSSDAY |
| 96 | VCPCNKLKSSDAYKK |
Function
t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8103915, PubMed:8243676). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834)
Protein Sequence
10
MAEDADMRNE
20
LEEMQRRADQ
30
LADESLESTR
40
RMLQLVEESK
50
DAGIRTLVML
60
DEQGEQLERI
70
EEGMDQINKD
80
MKEAEKNLTD
90
LGKFCGLCVC
100
PCNKLKSSDA
110
YKKAWGNNQD
120
GVVASQPARV
130
VDEREQMAIS
140
GGFIRRVTND
150
ARENEMDENL
160
EQVSGIIGNL
170
RHMALDMGNE
180
IDTQNRQIDR
190
IMEKADSNKT
200
RIDEANQRAT
KMLGSG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0031083 | BLOC-1 complex |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0098888 | extrinsic component of presynaptic membrane |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0097470 | ribbon synapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex |
| Cellular Component | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| Cellular Component | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0008076 | voltage-gated potassium channel complex |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0017022 | myosin binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0005249 | voltage-gated potassium channel activity |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0007626 | locomotory behavior |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:1903296 | positive regulation of glutamate secretion, neurotransmission |
| Biological Process | GO:0046887 | positive regulation of hormone secretion |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:1901387 | positive regulation of voltage-gated calcium channel activity |
| Biological Process | GO:0099525 | presynaptic dense core vesicle exocytosis |
| Biological Process | GO:0070201 | regulation of establishment of protein localization |
| Biological Process | GO:0010975 | regulation of neuron projection development |
| Biological Process | GO:0051963 | regulation of synapse assembly |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Biological Process | GO:1990926 | short-term synaptic potentiation |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane |
| Biological Process | GO:0016082 | synaptic vesicle priming |
| Biological Process | GO:0006906 | vesicle fusion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.