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Overview

Uniprot IDP60891
Protein NameRibose-phosphate pyrophosphokinase 1
Gene NamePRPS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
176 SPDAGGAKRVTSIAD
18 SHQDLSQKIADRLGL
194 VDFALIHKERKKANE
198 LIHKERKKANEVDRM
212 MVLVGDVKDRVAILV
34 LGKVVTKKFSNQETC

Function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis

Protein Sequence

10 MPNIKIFSGS 20 SHQDLSQKIA 30 DRLGLELGKV 40 VTKKFSNQET 50 CVEIGESVRG 60 EDVYIVQSGC 70 GEINDNLMEL 80 LIMINACKIA 90 SASRVTAVIP 100 CFPYARQDKK 110 DKSRAPISAK 120 LVANMLSVAG 130 ADHIITMDLH 140 ASQIQGFFDI 150 PVDNLYAEPA 160 VLKWIRENIS 170 EWRNCTIVSP 180 DAGGAKRVTS 190 IADRLNVDFA 200 LIHKERKKAN 210 EVDRMVLVGD 220 VKDRVAILVD 230 DMADTCGTIC 240 HAADKLLSAG 250 ATRVYAILTH 260 GIFSGPAISR 270 INNACFEAVV 280 VTNTIPQEDK 290 MKHCSKIQVI 300 DISMILAEAI 310 RRTHNGESVS YLFSHVPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0002189 ribose phosphate diphosphokinase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0016301 kinase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0004749 ribose phosphate diphosphokinase activity
Biological Process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
Biological Process GO:0046101 hypoxanthine biosynthetic process
Biological Process GO:0007399 nervous system development
Biological Process GO:0006144 purine nucleobase metabolic process
Biological Process GO:0006164 purine nucleotide biosynthetic process
Biological Process GO:0006221 pyrimidine nucleotide biosynthetic process
Biological Process GO:0009156 ribonucleoside monophosphate biosynthetic process
Biological Process GO:0034418 urate biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.