Search Results
Overview
| Uniprot ID | P60901 |
|---|---|
| Protein Name | Proteasome subunit alpha type-6 |
| Gene Name | Psma6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | RYEAANWKYKYGYEI |
| 181 | ESTSFLEKKVKKKFD |
| 45 | TSVAVRGKDCAVIVT |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097542 | ciliary tip |
| Cellular Component | GO:0000932 | P-body |
| Cellular Component | GO:0000502 | proteasome complex |
| Cellular Component | GO:0005839 | proteasome core complex |
| Cellular Component | GO:0019773 | proteasome core complex, alpha-subunit complex |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0097229 | sperm end piece |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0010498 | proteasomal protein catabolic process |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Biological Process | GO:0006979 | response to oxidative stress |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.