Search Results
Overview
| Uniprot ID | P60953 |
|---|---|
| Protein Name | Cell division control protein 42 homolog |
| Gene Name | CDC42 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | EITHHCPKTPFLLVG |
| 128 | DDPSTIEKLAKNKQK |
| 133 | IEKLAKNKQKPITPE |
| 144 | ITPETAEKLARDLKA |
| 153 | ARDLKAVKYVECSAL |
| 163 | ECSALTQKGLKNVFD |
| 96 | SFENVKEKWVPEITH |
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317, PubMed:22843693). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed:33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (PubMed:33310911). Negatively regulates polymerization of SEPTIN12, as a result may be involved in spermatogenesis (PubMed:30189608)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045177 | apical part of cell |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0032467 | positive regulation of cytokinesis |
| Biological Process | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0048549 | positive regulation of pinocytosis |
| Biological Process | GO:0031274 | positive regulation of pseudopodium assembly |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0051489 | regulation of filopodium assembly |
| Biological Process | GO:0010591 | regulation of lamellipodium assembly |
| Biological Process | GO:0099175 | regulation of postsynapse organization |
| Biological Process | GO:0051492 | regulation of stress fiber assembly |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0021762 | substantia nigra development |
| Biological Process | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0017119 | Golgi transport complex |
| Cellular Component | GO:0031256 | leading edge membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0051233 | spindle midzone |
| Cellular Component | GO:0000322 | storage vacuole |
| Molecular Function | GO:0034191 | apolipoprotein A-I receptor binding |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0032427 | GBD domain binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0030742 | GTP-dependent protein binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0031996 | thioesterase binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| Biological Process | GO:0034329 | cell junction assembly |
| Biological Process | GO:0060997 | dendritic spine morphogenesis |
| Biological Process | GO:0035050 | embryonic heart tube development |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0086100 | endothelin receptor signaling pathway |
| Biological Process | GO:0030010 | establishment of cell polarity |
| Biological Process | GO:0045198 | establishment of epithelial cell apical/basal polarity |
| Biological Process | GO:0051683 | establishment of Golgi localization |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0003015 | heart process |
| Biological Process | GO:0044788 | host-mediated perturbation of viral process |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0030225 | macrophage differentiation |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:0038189 | neuropilin signaling pathway |
| Biological Process | GO:0072384 | organelle transport along microtubule |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0030307 | positive regulation of cell growth |
Reference
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[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.