Search Results

Overview

Uniprot IDP60981
Protein NameDestrin
Gene NameDSTN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 KKKFQGIKHECQANG
22 FYDMKVRKCSTPEEI
44 IFCLSADKKCIIVEE
45 FCLSADKKCIIVEEG
53 CIIVEEGKEILVGDV
78 FVGMLPEKDCRYALY
92 YDASFETKESRKEEL

Function

Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

Protein Sequence

10 MASGVQVADE 20 VCRIFYDMKV 30 RKCSTPEEIK 40 KRKKAVIFCL 50 SADKKCIIVE 60 EGKEILVGDV 70 GVTITDPFKH 80 FVGMLPEKDC 90 RYALYDASFE 100 TKESRKEELM 110 FFLWAPELAP 120 LKSKMIYASS 130 KDAIKKKFQG 140 IKHECQANGP 150 EDLNRACIAE 160 KLGGSLIVAF EGCPV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0098793 presynapse
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0030042 actin filament depolymerization
Biological Process GO:0030043 actin filament fragmentation
Biological Process GO:0051014 actin filament severing
Biological Process GO:0008154 actin polymerization or depolymerization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.