Search Results

Overview

Uniprot ID	P60983
Protein Name	Glia maturation factor beta
Gene Name	GMFB
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
25	LRKFRFRKETNNAAI

Function

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells

Protein Sequence

10 MSESLVVCDV 20 AEDLVEKLRK 30 FRFRKETNNA 40 AIIMKIDKDK 50 RLVVLDEELE 60 GISPDELKDE 70 LPERQPRFIV 80 YSYKYQHDDG 90 RVSYPLCFIF 100 SSPVGCKPEQ 110 QMMYAGSKNK 120 LVQTAELTKV 130 FEIRNTEDLT 140 EEWLREKLGF FH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030864	cortical actin cytoskeleton
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0071933	Arp2/3 complex binding
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0008083	growth factor activity
Molecular Function	GO:0004860	protein kinase inhibitor activity
Biological Process	GO:0071846	actin filament debranching
Biological Process	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0006468	protein phosphorylation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.