Search Results
Overview
| Uniprot ID | P61006 |
|---|---|
| Protein Name | Ras-related protein Rab-8A |
| Gene Name | RAB8A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 176 | IKAKMDKKLEGNSPQ |
| 197 | KITPDQQKRSSFFRC |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148, PubMed:20631154). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0060170 | ciliary membrane |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0097730 | non-motile cilium |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Cellular Component | GO:0030140 | trans-Golgi network transport vesicle |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0031489 | myosin V binding |
| Molecular Function | GO:1990782 | protein tyrosine kinase binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0048210 | Golgi vesicle fusion to target membrane |
| Biological Process | GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane |
| Biological Process | GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane |
| Biological Process | GO:0061512 | protein localization to cilium |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0010506 | regulation of autophagy |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0051223 | regulation of protein transport |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.