Overview
| Uniprot ID | P61019 |
|---|
| Protein Name | Ras-related protein Rab-2A |
|---|
| Gene Name | RAB2A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
ESRREVKKEEGEAFA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915)
Protein Sequence
10
MAYAYLFKYI
20
IIGDTGVGKS
30
CLLLQFTDKR
40
FQPVHDLTIG
50
VEFGARMITI
60
DGKQIKLQIW
70
DTAGQESFRS
80
ITRSYYRGAA
90
GALLVYDITR
100
RDTFNHLTTW
110
LEDARQHSNS
120
NMVIMLIGNK
130
SDLESRREVK
140
KEEGEAFARE
150
HGLIFMETSA
160
KTASNVEEAF
170
INTAKEIYEK
180
IQEGVFDINN
190
EANGIKIGPQ
200
HAATNATHAG
210
NQGGQQAGGG
CC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001669 |
acrosomal vesicle |
| Cellular Component |
GO:0000421 |
autophagosome membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0061909 |
autophagosome-lysosome fusion |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.