Overview
| Uniprot ID | P61026 |
|---|
| Protein Name | Ras-related protein Rab-10 |
|---|
| Gene Name | RAB10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 4 |
****MAKKTYDLLFK |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). RAB10 is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, RAB10 regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220)
Protein Sequence
10
MAKKTYDLLF
20
KLLLIGDSGV
30
GKTCVLFRFS
40
DDAFNTTFIS
50
TIGIDFKIKT
60
VELQGKKIKL
70
QIWDTAGQER
80
FHTITTSYYR
90
GAMGIMLVYD
100
ITNGKSFENI
110
SKWLRNIDEH
120
ANEDVERMLL
130
GNKCDMDDKR
140
VVPKGKGEQI
150
AREHGIRFFE
160
TSAKANINIE
170
KAFLTLAEDI
180
LRKTPVKEPN
190
SENVDISSGG
200
GVTGWKSKCC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Molecular Function |
GO:0031489 |
myosin V binding |
| Biological Process |
GO:0019882 |
antigen processing and presentation |
| Biological Process |
GO:0007409 |
axonogenesis |
| Biological Process |
GO:0032869 |
cellular response to insulin stimulus |
| Biological Process |
GO:0071786 |
endoplasmic reticulum tubular network organization |
| Biological Process |
GO:0016197 |
endosomal transport |
| Biological Process |
GO:0045200 |
establishment of neuroblast polarity |
| Biological Process |
GO:0097051 |
establishment of protein localization to endoplasmic reticulum membrane |
| Biological Process |
GO:0090150 |
establishment of protein localization to membrane |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0043001 |
Golgi to plasma membrane protein transport |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:1905504 |
negative regulation of motile cilium assembly |
| Biological Process |
GO:0030859 |
polarized epithelial cell differentiation |
| Biological Process |
GO:1903361 |
protein localization to basolateral plasma membrane |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0045055 |
regulated exocytosis |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0071782 |
endoplasmic reticulum tubular network |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070382 |
exocytic vesicle |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0032593 |
insulin-responsive compartment |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0030667 |
secretory granule membrane |
| Cellular Component |
GO:0099503 |
secretory vesicle |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.