Search Results
Overview
| Uniprot ID | P61106 |
|---|---|
| Protein Name | Ras-related protein Rab-14 |
| Gene Name | RAB14 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 34 | LLHQFTEKKFMADCP |
| 35 | LHQFTEKKFMADCPH |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22595670). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (PubMed:22595670). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (PubMed:20534812). Interaction with RAB11FIP1 may function in the process of neurite formation (PubMed:26032412)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0005791 | rough endoplasmic reticulum |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0030140 | trans-Golgi network transport vesicle |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0031489 | myosin V binding |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0034498 | early endosome to Golgi transport |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0034058 | endosomal vesicle fusion |
| Biological Process | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| Biological Process | GO:0006895 | Golgi to endosome transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0046907 | intracellular transport |
| Biological Process | GO:0001845 | phagolysosome assembly |
| Biological Process | GO:0090382 | phagosome maturation |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0045335 | phagocytic vesicle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.