Overview
| Uniprot ID | P61107 |
|---|
| Protein Name | Ras-related protein Rab-14 |
|---|
| Gene Name | Rab14 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 171 |
AFLEAAKKIYQNIQD |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (PubMed:15004230). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity)
Protein Sequence
10
MATTPYNYSY
20
IFKYIIIGDM
30
GVGKSCLLHQ
40
FTEKKFMADC
50
PHTIGVEFGT
60
RIIEVSGQKI
70
KLQIWDTAGQ
80
ERFRAVTRSY
90
YRGAAGALMV
100
YDITRRSTYN
110
HLSSWLTDAR
120
NLTNPNTVII
130
LIGNKADLEA
140
QRDVTYEEAK
150
QFAEENGLLF
160
LEASAKTGEN
170
VEDAFLEAAK
180
KIYQNIQDGS
190
LDLNAAESGV
200
QHKPSAPQGG
210
RLTSEPQPQR
EGCGC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097208 |
alveolar lamellar body |
| Cellular Component |
GO:0005791 |
rough endoplasmic reticulum |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Cellular Component |
GO:0030140 |
trans-Golgi network transport vesicle |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0031489 |
myosin V binding |
| Biological Process |
GO:0045176 |
apical protein localization |
| Biological Process |
GO:0007589 |
body fluid secretion |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0034498 |
early endosome to Golgi transport |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0034058 |
endosomal vesicle fusion |
| Biological Process |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
| Biological Process |
GO:0006895 |
Golgi to endosome transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0046907 |
intracellular transport |
| Biological Process |
GO:0001845 |
phagolysosome assembly |
| Biological Process |
GO:0045995 |
regulation of embryonic development |
| Biological Process |
GO:0032880 |
regulation of protein localization |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Cellular Component |
GO:0005770 |
late endosome |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0042175 |
nuclear outer membrane-endoplasmic reticulum membrane network |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.