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Overview

Uniprot IDP61201
Protein NameCOP9 signalosome complex subunit 2
Gene NameCOPS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
426 ARYTALDKWTNQLNS
93 PEMMNRYKQLLTYIR

Function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1

Protein Sequence

10 MSDMEDDFMC 20 DDEEDYDLEY 30 SEDSNSEPNV 40 DLENQYYNSK 50 ALKEDDPKAA 60 LSSFQKVLEL 70 EGEKGEWGFK 80 ALKQMIKINF 90 KLTNFPEMMN 100 RYKQLLTYIR 110 SAVTRNYSEK 120 SINSILDYIS 130 TSKQMDLLQE 140 FYETTLEALK 150 DAKNDRLWFK 160 TNTKLGKLYL 170 EREEYGKLQK 180 ILRQLHQSCQ 190 TDDGEDDLKK 200 GTQLLEIYAL 210 EIQMYTAQKN 220 NKKLKALYEQ 230 SLHIKSAIPH 240 PLIMGVIREC 250 GGKMHLREGE 260 FEKAHTDFFE 270 AFKNYDESGS 280 PRRTTCLKYL 290 VLANMLMKSG 300 INPFDSQEAK 310 PYKNDPEILA 320 MTNLVSAYQN 330 NDITEFEKIL 340 KTNHSNIMDD 350 PFIREHIEEL 360 LRNIRTQVLI 370 KLIKPYTRIH 380 IPFISKELNI 390 DVADVESLLV 400 QCILDNTIHG 410 RIDQVNQLLE 420 LDHQKRGGAR 430 YTALDKWTNQ 440 LNSLNQAVVS KLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008180 COP9 signalosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0000338 protein deneddylation
Biological Process GO:0045116 protein neddylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:2000434 regulation of protein neddylation
Biological Process GO:0007165 signal transduction
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.