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Overview

Uniprot IDP61206
Protein NameADP-ribosylation factor 3
Gene NameArf3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
73 WDVGGQDKIRPLWRH

Function

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Protein Sequence

10 MGNIFGNLLK 20 SLIGKKEMRI 30 LMVGLDAAGK 40 TTILYKLKLG 50 EIVTTIPTIG 60 FNVETVEYKN 70 ISFTVWDVGG 80 QDKIRPLWRH 90 YFQNTQGLIF 100 VVDSNDRERV 110 NEAREELMRM 120 LAEDELRDAV 130 LLVFANKQDL 140 PNAMNAAEIT 150 DKLGLHSLRH 160 RNWYIQATCA 170 TSGDGLYEGL 180 DWLANQLKNK K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.