Search Results
Overview
| Uniprot ID | P61224 |
|---|---|
| Protein Name | Ras-related protein Rap-1b |
| Gene Name | RAP1B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | REQILRVKDTDDVPM |
| 117 | PMILVGNKCDLEDER |
| 128 | EDERVVGKEQGQNLA |
| 174 | RKTPVPGKARKKSSC |
Function
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0099010 | modification of postsynaptic structure |
| Biological Process | GO:2000301 | negative regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0033625 | positive regulation of integrin activation |
| Biological Process | GO:0032486 | Rap protein signal transduction |
| Biological Process | GO:1901888 | regulation of cell junction assembly |
| Biological Process | GO:2000114 | regulation of establishment of cell polarity |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005811 | lipid droplet |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.