Search Results
Overview
| Uniprot ID | P61244 |
|---|---|
| Protein Name | Protein max |
| Gene Name | MAX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | RKRRDHIKDSFHSLR |
| 66 | SRAQILDKATEYIQY |
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements
Protein Sequence
10
MSDNDDIEVE
20
SDEEQPRFQS
30
AADKRAHHNA
40
LERKRRDHIK
50
DSFHSLRDSV
60
PSLQGEKASR
70
AQILDKATEY
80
IQYMRRKNHT
90
HQQDIDDLKR
100
QNALLEQQVR
110
ALEKARSSAQ
120
LQTNYPSSDN
130
SLYTNAKGST
140
ISAFDGGSDS
150
SSESEPEEPQ
160
SRKKLRMEAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0071339 | MLL1 complex |
| Cellular Component | GO:0071943 | Myc-Max complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A