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Overview

Uniprot IDP61288
Protein NameTranslationally-controlled tumor protein
Gene NameTPT1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
102 YMKSIKGKLEEQRPE
93 EAYKKYIKDYMKSIK
97 KYIKDYMKSIKGKLE

Function

Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity)

Protein Sequence

10 MIIYRDLISH 20 DEMFSDIYKI 30 REIADGLCLE 40 VEGKMVSRTE 50 GNIDDSLIGG 60 NASAEGPEGE 70 GTESTVITGV 80 DIVMNHHLQE 90 TSFTKEAYKK 100 YIKDYMKSIK 110 GKLEEQRPER 120 VKPFMTGAAE 130 QIKHILANFK 140 NYQFFIGENM 150 NPDGMVALLD 160 YREDGVTPYM 170 IFFKDGLEME KC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005771 multivesicular body
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0005509 calcium ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.