Overview
| Uniprot ID | P61289 |
|---|
| Protein Name | Proteasome activator complex subunit 3 |
|---|
| Gene Name | PSME3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 14 |
VDQEVKLKVDSFRER |
| 195 |
KLVSKIAKYPHVEDY |
| 6 |
**MASLLKVDQEVKL |
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978)
Protein Sequence
10
MASLLKVDQE
20
VKLKVDSFRE
30
RITSEAEDLV
40
ANFFPKKLLE
50
LDSFLKEPIL
60
NIHDLTQIHS
70
DMNLPVPDPI
80
LLTNSHDGLD
90
GPTYKKRRLD
100
ECEEAFQGTK
110
VFVMPNGMLK
120
SNQQLVDIIE
130
KVKPEIRLLI
140
EKCNTVKMWV
150
QLLIPRIEDG
160
NNFGVSIQEE
170
TVAELRTVES
180
EAASYLDQIS
190
RYYITRAKLV
200
SKIAKYPHVE
210
DYRRTVTEID
220
EKEYISLRLI
230
ISELRNQYVT
240
LHDMILKNIE
250
KIKRPRSSNA
ETLY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0008537 |
proteasome activator complex |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0034515 |
proteasome storage granule |
| Molecular Function |
GO:0061133 |
endopeptidase activator activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0097371 |
MDM2/MDM4 family protein binding |
| Molecular Function |
GO:0002039 |
p53 binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0030317 |
flagellated sperm motility |
| Biological Process |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process |
GO:2000045 |
regulation of G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.