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Overview

Uniprot IDP61313
Protein NameLarge ribosomal subunit protein eL15
Gene NameRPL15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 IQELWRKKQSDVMRF
153 PDTQWITKPVHKHRE
179 RGLGKGHKFHHTIGG
56 RRLGYKAKQGYVIYR
83 PKGATYGKPVHHGVN
93 HHGVNQLKFARSLQS

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Protein Sequence

10 MGAYKYIQEL 20 WRKKQSDVMR 30 FLLRVRCWQY 40 RQLSALHRAP 50 RPTRPDKARR 60 LGYKAKQGYV 70 IYRIRVRRGG 80 RKRPVPKGAT 90 YGKPVHHGVN 100 QLKFARSLQS 110 VAEERAGRHC 120 GALRVLNSYW 130 VGEDSTYKFF 140 EVILIDPFHK 150 AIRRNPDTQW 160 ITKPVHKHRE 170 MRGLTSAGRK 180 SRGLGKGHKF 190 HHTIGGSRRA 200 AWRRRNTLQL HRYR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005840 ribosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:1901740 negative regulation of myoblast fusion
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0006412 translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.