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Overview

Uniprot IDP61354
Protein NameLarge ribosomal subunit protein eL27
Gene NameRpl27
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
128 RYKTGKNKWFFQKLR
52 GIDRYPRKVTAAMGK
73 SKIKSFVKVYNYNHL
93 SVDIPLDKTVVNKDV
98 LDKTVVNKDVFRDPA

Function

Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)

Protein Sequence

10 MGKFMKPGKV 20 VLVLAGRYSG 30 RKAVIVKNID 40 DGTSDRPYSH 50 ALVAGIDRYP 60 RKVTAAMGKK 70 KIAKRSKIKS 80 FVKVYNYNHL 90 MPTRYSVDIP 100 LDKTVVNKDV 110 FRDPALKRKA 120 RREAKVKFEE 130 RYKTGKNKWF FQKLRF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0015934 large ribosomal subunit
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005840 ribosome
Cellular Component GO:0045202 synapse
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:1904044 response to aldosterone
Biological Process GO:0006364 rRNA processing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.