Search Results
Overview
| Uniprot ID | P61457 |
|---|---|
| Protein Name | Pterin-4-alpha-carbinolamine dehydratase |
| Gene Name | PCBD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | EGRDAIFKQFHFKDF |
| 41 | IFKQFHFKDFNRAFG |
| 59 | RVALQAEKLDHHPEW |
Function
Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001)
Protein Sequence
10
MAGKAHRLSA
20
EERDQLLPNL
30
RAVGWNELEG
40
RDAIFKQFHF
50
KDFNRAFGFM
60
TRVALQAEKL
70
DHHPEWFNVY
80
NKVHITLSTH
90
ECAGLSERDI
100
NLASFIEQVA
VSMT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0008124 | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004505 | phenylalanine 4-monooxygenase activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006729 | tetrahydrobiopterin biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.