Search Results
Overview
| Uniprot ID | P61758 |
|---|---|
| Protein Name | Prefoldin subunit 3 |
| Gene Name | VBP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | AVKDSCGKGEMATGN |
| 153 | KNLSTATKNLDSLEE |
| 5 | ***MAAVKDSCGKGE |
| 59 | KLDEQYQKYKFMELN |
| 70 | MELNLAQKKRRLKGQ |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins
Protein Sequence
10
MAAVKDSCGK
20
GEMATGNGRR
30
LHLGIPEAVF
40
VEDVDSFMKQ
50
PGNETADTVL
60
KKLDEQYQKY
70
KFMELNLAQK
80
KRRLKGQIPE
90
IKQTLEILKY
100
MQKKKESTNS
110
METRFLLADN
120
LYCKASVPPT
130
DKVCLWLGAN
140
VMLEYDIDEA
150
QALLEKNLST
160
ATKNLDSLEE
170
DLDFLRDQFT
180
TTEVNMARVY
190
NWDVKRRNKD
DSTKNKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016272 | prefoldin complex |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.