Search Results
Overview
| Uniprot ID | P61765 |
|---|---|
| Protein Name | Syntaxin-binding protein 1 |
| Gene Name | Stxbp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | LKAVVGEKIMHDVIK |
| 165 | SPHKAQMKNPILERL |
| 20 | KIMHDVIKKVKKKGE |
| 213 | QDKLDAYKADDPTMG |
| 225 | TMGEGPDKARSQLLI |
| 294 | LWIALRHKHIAEVSQ |
| 308 | QEVTRSLKDFSSSKR |
| 321 | KRMNTGEKTTMRDLS |
| 333 | DLSQMLKKMPQYQKE |
| 339 | KKMPQYQKELSKYST |
| 343 | QYQKELSKYSTHLHL |
| 364 | HYQGTVDKLCRVEQD |
| 493 | MEDTIEDKLDTKHYP |
| 497 | IEDKLDTKHYPYIST |
| 524 | ARYGHWHKNKAPGEY |
| 526 | YGHWHKNKAPGEYRS |
| 583 | QKLLDTLKKLNKTDE |
| 92 | HSLISDFKDPPTAKY |
| 98 | FKDPPTAKYRAAHVF |
Function
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions
Protein Sequence
10
MAPIGLKAVV
20
GEKIMHDVIK
30
KVKKKGEWKV
40
LVVDQLSMRM
50
LSSCCKMTDI
60
MTEGITIVED
70
INKRREPLPS
80
LEAVYLITPS
90
EKSVHSLISD
100
FKDPPTAKYR
110
AAHVFFTDSC
120
PDALFNELVK
130
SRAAKVIKTL
140
TEINIAFLPY
150
ESQVYSLDSA
160
DSFQSFYSPH
170
KAQMKNPILE
180
RLAEQIATLC
190
ATLKEYPAVR
200
YRGEYKDNAL
210
LAQLIQDKLD
220
AYKADDPTMG
230
EGPDKARSQL
240
LILDRGFDPS
250
SPVLHELTFQ
260
AMSYDLLPIE
270
NDVYKYETSG
280
IGEARVKEVL
290
LDEDDDLWIA
300
LRHKHIAEVS
310
QEVTRSLKDF
320
SSSKRMNTGE
330
KTTMRDLSQM
340
LKKMPQYQKE
350
LSKYSTHLHL
360
AEDCMKHYQG
370
TVDKLCRVEQ
380
DLAMGTDAEG
390
EKIKDPMRAI
400
VPILLDANVS
410
TYDKIRIILL
420
YIFLKNGITE
430
ENLNKLIQHA
440
QIPPEDSEII
450
TNMAHLGVPI
460
VTDSTLRRRS
470
KPERKERISE
480
QTYQLSRWTP
490
IIKDIMEDTI
500
EDKLDTKHYP
510
YISTRSSASF
520
STTAVSARYG
530
HWHKNKAPGE
540
YRSGPRLIIF
550
ILGGVSLNEM
560
RCAYEVTQAN
570
GKWEVLIGST
580
HILTPQKLLD
590
TLKKLNKTDE
EISS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098888 | extrinsic component of presynaptic membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031091 | platelet alpha granule |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0098831 | presynaptic active zone cytoplasmic component |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0007412 | axon target recognition |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0003006 | developmental process involved in reproduction |
| Biological Process | GO:0061670 | evoked neurotransmitter secretion |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0060292 | long-term synaptic depression |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:0035544 | negative regulation of SNARE complex assembly |
| Biological Process | GO:0032229 | negative regulation of synaptic transmission, GABAergic |
| Biological Process | GO:0007274 | neuromuscular synaptic transmission |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0002576 | platelet degranulation |
| Biological Process | GO:0045956 | positive regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:1903296 | positive regulation of glutamate secretion, neurotransmission |
| Biological Process | GO:0043306 | positive regulation of mast cell degranulation |
| Biological Process | GO:0010808 | positive regulation of synaptic vesicle priming |
| Biological Process | GO:0106022 | positive regulation of vesicle docking |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:0099525 | presynaptic dense core vesicle exocytosis |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:2000367 | regulation of acrosomal vesicle exocytosis |
| Biological Process | GO:0010807 | regulation of synaptic vesicle priming |
| Biological Process | GO:0031338 | regulation of vesicle fusion |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0016188 | synaptic vesicle maturation |
| Biological Process | GO:0016082 | synaptic vesicle priming |
| Biological Process | GO:0006904 | vesicle docking involved in exocytosis |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.