Search Results
Overview
| Uniprot ID | P61769 |
|---|---|
| Protein Name | Beta-2-microglobulin |
| Gene Name | B2M |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | HVTLSQPKIVKWDRD |
| 68 | KNGERIEKVEHSDLS |
| 95 | TEFTPTEKDEYACRV |
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)
Protein Sequence
10
MSRSVALAVL
20
ALLSLSGLEA
30
IQRTPKIQVY
40
SRHPAENGKS
50
NFLNCYVSGF
60
HPSDIEVDLL
70
KNGERIEKVE
80
HSDLSFSKDW
90
SFYLLYYTEF
100
TPTEKDEYAC
110
RVNHVTLSQP
KIVKWDRDM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031905 | early endosome lumen |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:1990712 | HFE-transferrin receptor complex |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0042612 | MHC class I protein complex |
| Cellular Component | GO:0042613 | MHC class II protein complex |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0042605 | peptide antigen binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| Biological Process | GO:0002477 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| Biological Process | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| Biological Process | GO:0071281 | cellular response to iron ion |
| Biological Process | GO:0071316 | cellular response to nicotine |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:2000978 | negative regulation of forebrain neuron differentiation |
| Biological Process | GO:0034757 | negative regulation of iron ion transport |
| Biological Process | GO:0050768 | negative regulation of neurogenesis |
| Biological Process | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0002503 | peptide antigen assembly with MHC class II protein complex |
| Biological Process | GO:2000774 | positive regulation of cellular senescence |
| Biological Process | GO:0050778 | positive regulation of immune response |
| Biological Process | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| Biological Process | GO:0050870 | positive regulation of T cell activation |
| Biological Process | GO:0002726 | positive regulation of T cell cytokine production |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0034756 | regulation of iron ion transport |
| Biological Process | GO:0002715 | regulation of natural killer cell mediated immunity |
| Biological Process | GO:0007608 | sensory perception of smell |
| Biological Process | GO:0033572 | transferrin transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.