Search Results
Overview
| Uniprot ID | P61916 |
|---|---|
| Protein Name | NPC intracellular cholesterol transporter 2 |
| Gene Name | NPC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | NCPIQKDKTYSYLNK |
| 116 | YLNKLPVKSEYPSIK |
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Biological Process | GO:0019747 | regulation of isoprenoid metabolic process |
| Biological Process | GO:0009615 | response to virus |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0120020 | cholesterol transfer activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0046836 | glycolipid transport |
| Biological Process | GO:0032367 | intracellular cholesterol transport |
| Biological Process | GO:0032366 | intracellular sterol transport |
| Biological Process | GO:0090120 | lysosome to ER cholesterol transport |
| Biological Process | GO:0015914 | phospholipid transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.