Overview
| Uniprot ID | P61959 |
|---|
| Protein Name | Small ubiquitin-related modifier 2 |
|---|
| Gene Name | Sumo2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 45 |
TPLSKLMKAYCERQG |
| 7 |
*MADEKPKEGVKTEN |
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity)
Protein Sequence
10
MADEKPKEGV
20
KTENNDHINL
30
KVAGQDGSVV
40
QFKIKRHTPL
50
SKLMKAYCER
60
QGLSMRQIRF
70
RFDGQPINET
80
DTPAQLEMED
90
EDTIDVFQQQ
TGGVY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0098686 |
hippocampal mossy fiber to CA3 synapse |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016605 |
PML body |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0099524 |
postsynaptic cytosol |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Molecular Function |
GO:0046965 |
nuclear retinoid X receptor binding |
| Molecular Function |
GO:0031386 |
protein tag activity |
| Molecular Function |
GO:0019789 |
SUMO transferase activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Molecular Function |
GO:0044389 |
ubiquitin-like protein ligase binding |
| Biological Process |
GO:0008104 |
intracellular protein localization |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0033235 |
positive regulation of protein sumoylation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0016925 |
protein sumoylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.