Search Results

Overview

Uniprot ID	P61979
Protein Name	Heterogeneous nuclear ribonucleoprotein K
Gene Name	Hnrnpk
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
405	LAGSIIGKGGQRIKQ

Function

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity)

Protein Sequence

10 METEQPEETF 20 PNTETNGEFG 30 KRPAEDMEEE 40 QAFKRSRNTD 50 EMVELRILLQ 60 SKNAGAVIGK 70 GGKNIKALRT 80 DYNASVSVPD 90 SSGPERILSI 100 SADIETIGEI 110 LKKIIPTLEE 120 GLQLPSPTAT 130 SQLPLESDAV 140 ECLNYQHYKG 150 SDFDCELRLL 160 IHQSLAGGII 170 GVKGAKIKEL 180 RENTQTTIKL 190 FQECCPHSTD 200 RVVLIGGKPD 210 RVVECIKIIL 220 DLISESPIKG 230 RAQPYDPNFY 240 DETYDYGGFT 250 MMFDDRRGRP 260 VGFPMRGRGG 270 FDRMPPGRGG 280 RPMPPSRRDY 290 DDMSPRRGPP 300 PPPPGRGGRG 310 GSRARNLPLP 320 PPPPPRGGDL 330 MAYDRRGRPG 340 DRYDGMVGFS 350 ADETWDSAID 360 TWSPSEWQMA 370 YEPQGGSGYD 380 YSYAGGRGSY 390 GDLGGPIITT 400 QVTIPKDLAG 410 SIIGKGGQRI 420 KQIRHESGAS 430 IKIDEPLEGS 440 EDRIITITGT 450 QDQIQNAQYL 460 LQNSVKQYSG KFF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0002102	podosome
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0032993	protein-DNA complex
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0042805	actinin binding
Molecular Function	GO:0051117	ATPase binding
Molecular Function	GO:1990829	C-rich single-stranded DNA binding
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005521	lamin binding
Molecular Function	GO:0106222	lncRNA binding
Molecular Function	GO:0003730	mRNA 3'-UTR binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:1990715	mRNA CDS binding
Molecular Function	GO:0030628	pre-mRNA 3'-splice site binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0043021	ribonucleoprotein complex binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003697	single-stranded DNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0060816	random inactivation of X chromosome
Biological Process	GO:1902165	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process	GO:0048024	regulation of mRNA splicing, via spliceosome
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0031048	regulatory ncRNA-mediated heterochromatin formation
Biological Process	GO:0008380	RNA splicing
Cellular Component	GO:0043679	axon terminus

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.