Search Results
Overview
| Uniprot ID | P61980 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein K |
| Gene Name | Hnrnpk |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | AGGIIGVKGAKIKEL |
| 198 | RVVLIGGKPDRVVEC |
| 219 | LISESPIKGRAQPYD |
| 34 | MEEEQAFKRSRNTDE |
| 405 | LAGSIIGKGGQRIKQ |
| 52 | LRILLQSKNAGAVIG |
| 60 | NAGAVIGKGGKNIKA |
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity)
Protein Sequence
10
METEQPEETF
20
PNTETNGEFG
30
KRPAEDMEEE
40
QAFKRSRNTD
50
EMVELRILLQ
60
SKNAGAVIGK
70
GGKNIKALRT
80
DYNASVSVPD
90
SSGPERILSI
100
SADIETIGEI
110
LKKIIPTLEE
120
GLQLPSPTAT
130
SQLPLESDAV
140
ECLNYQHYKG
150
SDFDCELRLL
160
IHQSLAGGII
170
GVKGAKIKEL
180
RENTQTTIKL
190
FQECCPHSTD
200
RVVLIGGKPD
210
RVVECIKIIL
220
DLISESPIKG
230
RAQPYDPNFY
240
DETYDYGGFT
250
MMFDDRRGRP
260
VGFPMRGRGG
270
FDRMPPGRGG
280
RPMPPSRRDY
290
DDMSPRRGPP
300
PPPPGRGGRG
310
GSRARNLPLP
320
PPPPPRGGDL
330
MAYDRRGRPG
340
DRYDGMVGFS
350
ADETWDSAID
360
TWSPSEWQMA
370
YEPQGGSGYD
380
YSYAGGRGSY
390
GDLGGPIITT
400
QVTIPKDLAG
410
SIIGKGGQRI
420
KQIRHESGAS
430
IKIDEPLEGS
440
EDRIITITGT
450
QDQIQNAQYL
460
LQNSVKQYSG
KFF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0032993 | protein-DNA complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0042805 | actinin binding |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:1990829 | C-rich single-stranded DNA binding |
| Molecular Function | GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005521 | lamin binding |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:1990715 | mRNA CDS binding |
| Molecular Function | GO:0030628 | pre-mRNA 3'-splice site binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0043010 | camera-type eye development |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:1904322 | cellular response to forskolin |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071284 | cellular response to lead ion |
| Biological Process | GO:0072752 | cellular response to rapamycin |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0008584 | male gonad development |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:2000173 | negative regulation of branching morphogenesis of a nerve |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0007422 | peripheral nervous system development |
| Biological Process | GO:1903861 | positive regulation of dendrite extension |
| Biological Process | GO:0060999 | positive regulation of dendritic spine development |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:2000010 | positive regulation of protein localization to cell surface |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
| Biological Process | GO:0090129 | positive regulation of synapse maturation |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060816 | random inactivation of X chromosome |
| Biological Process | GO:1902165 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0099175 | regulation of postsynapse organization |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031048 | regulatory ncRNA-mediated heterochromatin formation |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:1902074 | response to salt |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0048538 | thymus development |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.