Search Results
Overview
| Uniprot ID | P61982 |
|---|---|
| Protein Name | 14-3-3 protein gamma |
| Gene Name | Ywhag |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 142 | AEVATGEKRATVVES |
| 69 | VISSIEQKTSADGNE |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (By similarity). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (By similarity). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005159 | insulin-like growth factor receptor binding |
| Molecular Function | GO:0140031 | phosphorylation-dependent protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Biological Process | GO:0034198 | cellular response to amino acid starvation |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0031669 | cellular response to nutrient levels |
| Biological Process | GO:0002181 | cytoplasmic translation |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0050868 | negative regulation of T cell activation |
| Biological Process | GO:0002841 | negative regulation of T cell mediated immune response to tumor cell |
| Biological Process | GO:1904262 | negative regulation of TORC1 signaling |
| Biological Process | GO:0045947 | negative regulation of translational initiation |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:0050870 | positive regulation of T cell activation |
| Biological Process | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell |
| Biological Process | GO:1904263 | positive regulation of TORC1 signaling |
| Biological Process | GO:0045948 | positive regulation of translational initiation |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0085020 | protein K6-linked ubiquitination |
| Biological Process | GO:0061462 | protein localization to lysosome |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0038202 | TORC1 signaling |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.