Search Results
Overview
| Uniprot ID | P61983 |
|---|---|
| Protein Name | 14-3-3 protein gamma |
| Gene Name | Ywhag |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | DREQLVQKARLAEQA |
| 142 | AEVATGEKRATVVES |
| 152 | TVVESSEKAYSEAHE |
| 162 | SEAHEISKEHMQPTH |
| 69 | VISSIEQKTSADGNE |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1. Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes. Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0030234 | enzyme regulator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005159 | insulin-like growth factor receptor binding |
| Molecular Function | GO:0140031 | phosphorylation-dependent protein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:1904262 | negative regulation of TORC1 signaling |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:0050870 | positive regulation of T cell activation |
| Biological Process | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0045664 | regulation of neuron differentiation |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.