Search Results
Overview
| Uniprot ID | P62068 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 46 |
| Gene Name | USP46 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 67 | RENVLAYKAQQKKKE |
Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014)
Protein Sequence
10
MTVRNIASIC
20
NMGTNASALE
30
KDIGPEQFPI
40
NEHYFGLVNF
50
GNTCYCNSVL
60
QALYFCRPFR
70
ENVLAYKAQQ
80
KKKENLLTCL
90
ADLFHSIATQ
100
KKKVGVIPPK
110
KFISRLRKEN
120
DLFDNYMQQD
130
AHEFLNYLLN
140
TIADILQEEK
150
KQEKQNGKLK
160
NGNMNEPAEN
170
NKPELTWVHE
180
IFQGTLTNET
190
RCLNCETVSS
200
KDEDFLDLSV
210
DVEQNTSITH
220
CLRDFSNTET
230
LCSEQKYYCE
240
TCCSKQEAQK
250
RMRVKKLPMI
260
LALHLKRFKY
270
MEQLHRYTKL
280
SYRVVFPLEL
290
RLFNTSSDAV
300
NLDRMYDLVA
310
VVVHCGSGPN
320
RGHYITIVKS
330
HGFWLLFDDD
340
IVEKIDAQAI
350
EEFYGLTSDI
360
SKNSESGYIL
FYQSRE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0032228 | regulation of synaptic transmission, GABAergic |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.