Search Results
Overview
| Uniprot ID | P62074 |
|---|---|
| Protein Name | Mitochondrial import inner membrane translocase subunit Tim10 |
| Gene Name | Timm10 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 45 | YKEAELSKGESVCLD |
Function
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)
Protein Sequence
10
MDPLRAQQLA
20
AELEVEMMAD
30
MYNRMTSACH
40
RKCVPPHYKE
50
AELSKGESVC
60
LDRCVSKYLD
70
IHERMGKKLT
80
ELSMQDEELM
90
KRVQQSSGPA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0042719 | mitochondrial intermembrane space chaperone complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0042721 | TIM22 mitochondrial import inner membrane insertion complex |
| Molecular Function | GO:0032977 | membrane insertase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.