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Overview

Uniprot ID	P62193
Protein Name	26S proteasome regulatory subunit 4
Gene Name	Psmc1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
24	DDKDKKKKYEPPVPT

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MGQSQSGGHG 20 PGGGKKDDKD 30 KKKKYEPPVP 40 TRVGKKKKKT 50 KGPDAASKLP 60 LVTPHTQCRL 70 KLLKLERIKD 80 YLLMEEEFIR 90 NQEQMKPLEE 100 KQEEERSKVD 110 DLRGTPMSVG 120 TLEEIIDDNH 130 AIVSTSVGSE 140 HYVSILSFVD 150 KDLLEPGCSV 160 LLNHKVHAVI 170 GVLMDDTDPL 180 VTVMKVEKAP 190 QETYADIGGL 200 DNQIQEIKES 210 VELPLTHPEY 220 YEEMGIKPPK 230 GVILYGPPGT 240 GKTLLAKAVA 250 NQTSATFLRV 260 VGSELIQKYL 270 GDGPKLVREL 280 FRVAEEHAPS 290 IVFIDEIDAI 300 GTKRYDSNSG 310 GEREIQRTML 320 ELLNQLDGFD 330 SRGDVKVIMA 340 TNRIETLDPA 350 LIRPGRIDRK 360 IEFPLPDEKT 370 KKRIFQIHTS 380 RMTLADDVTL 390 DDLIMAKDDL 400 SGADIKAICT 410 EAGLMALRER 420 RMKVTNEDFK 430 KSKENVLYKK 440 QEGTPEGLYL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0022624	proteasome accessory complex
Cellular Component	GO:0000502	proteasome complex
Cellular Component	GO:0005838	proteasome regulatory particle
Cellular Component	GO:0008540	proteasome regulatory particle, base subcomplex
Cellular Component	GO:0008021	synaptic vesicle
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0036402	proteasome-activating activity
Molecular Function	GO:0017025	TBP-class protein binding
Biological Process	GO:0010498	proteasomal protein catabolic process
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:2000311	regulation of AMPA receptor activity

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.