Overview
| Uniprot ID | P62198 |
|---|
| Protein Name | 26S proteasome regulatory subunit 8 |
|---|
| Gene Name | Psmc5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 55 |
QRNELNAKVRLLREE |
| 88 |
DKKKVLVKVHPEGKF |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MALDGPEQME
20
LEEGKAGSGL
30
RQYYLSKIEE
40
LQLIVNDKSQ
50
NLRRLQAQRN
60
ELNAKVRLLR
70
EELQLLQEQG
80
SYVGEVVRAM
90
DKKKVLVKVH
100
PEGKFVVDVD
110
KNIDINDVTP
120
NCRVALRNDS
130
YTLHKILPNK
140
VDPLVSLMMV
150
EKVPDSTYEM
160
IGGLDKQIKE
170
IKEVIELPVK
180
HPELFEALGI
190
AQPKGVLLYG
200
PPGTGKTLLA
210
RAVAHHTDCT
220
FIRVSGSELV
230
QKFIGEGARM
240
VRELFVMARE
250
HAPSIIFMDE
260
IDSIGSSRLE
270
GGSGGDSEVQ
280
RTMLELLNQL
290
DGFEATKNIK
300
VIMATNRIDI
310
LDSALLRPGR
320
IDRKIEFPPP
330
NEEARLDILK
340
IHSRKMNLTR
350
GINLRKIAEL
360
MPGASGAEVK
370
GVCTEAGMYA
380
LRERRVHVTQ
390
EDFEMAVAKV
400
MQKDSEKNMS
IKKLWK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031597 |
cytosolic proteasome complex |
| Cellular Component |
GO:0016234 |
inclusion body |
| Cellular Component |
GO:0031595 |
nuclear proteasome complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0022624 |
proteasome accessory complex |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0005838 |
proteasome regulatory particle |
| Cellular Component |
GO:0008540 |
proteasome regulatory particle, base subcomplex |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0140297 |
DNA-binding transcription factor binding |
| Molecular Function |
GO:0140296 |
general transcription initiation factor binding |
| Molecular Function |
GO:0036402 |
proteasome-activating activity |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0017025 |
TBP-class protein binding |
| Molecular Function |
GO:0031531 |
thyrotropin-releasing hormone receptor binding |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0090261 |
positive regulation of inclusion body assembly |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:2000311 |
regulation of AMPA receptor activity |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.