Search Results
Overview
| Uniprot ID | P62246 |
|---|---|
| Protein Name | Small ribosomal subunit protein uS8 |
| Gene Name | Rps15a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 84 | PRFDVQLKDLEKWQN |
Function
Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis
Protein Sequence
10
MVRMNVLADA
20
LKSINNAEKR
30
GKRQVLIRPC
40
SKVIVRFLTV
50
MMKHGYIGEF
60
EIIDDHRAGK
70
IVVNLTGRLN
80
KCGVISPRFD
90
VQLKDLEKWQ
100
NNLLPSRQFG
110
FIVLTTSAGI
120
MDHEEARRKH
130
TGGKILGFFF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
| Cellular Component | GO:0032040 | small-subunit processome |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0045787 | positive regulation of cell cycle |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0006412 | translation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.