Search Results
Overview
| Uniprot ID | P62258 |
|---|---|
| Protein Name | 14-3-3 protein epsilon |
| Gene Name | YWHAE |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | AANTGESKVFYYKMK |
| 12 | EDLVYQAKLAEQAER |
| 142 | FATGNDRKEAAENSL |
| 28 | DEMVESMKKVAGMDV |
| 29 | EMVESMKKVAGMDVE |
| 50 | NLLSVAYKNVIGARR |
| 69 | IISSIEQKEENKGGE |
| 73 | IEQKEENKGGEDKLK |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0019899 | enzyme binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0050815 | phosphoserine residue binding |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0086013 | membrane repolarization during cardiac muscle cell action potential |
| Biological Process | GO:1905913 | negative regulation of calcium ion export across plasma membrane |
| Biological Process | GO:0042308 | negative regulation of protein import into nucleus |
| Biological Process | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| Biological Process | GO:0035332 | positive regulation of hippo signaling |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:0070972 | protein localization to endoplasmic reticulum |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0003064 | regulation of heart rate by hormone |
| Biological Process | GO:0060306 | regulation of membrane repolarization |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
| Biological Process | GO:1901379 | regulation of potassium ion transmembrane transport |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.