Search Results
Overview
| Uniprot ID | P62260 |
|---|---|
| Protein Name | 14-3-3 protein epsilon |
| Gene Name | Ywhae |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | DILDVLDKHLIPAAN |
| 118 | AANTGESKVFYYKMK |
| 12 | EDLVYQAKLAEQAER |
| 125 | KVFYYKMKGDYHRYL |
| 142 | FATGNDRKEAAENSL |
| 28 | DEMVESMKKVAGMDV |
| 50 | NLLSVAYKNVIGARR |
| 69 | IISSIEQKEENKGGE |
| 78 | ENKGGEDKLKMIREY |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0090724 | central region of growth cone |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0050815 | phosphoserine residue binding |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0008426 | protein kinase C inhibitor activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:1905913 | negative regulation of calcium ion export across plasma membrane |
| Biological Process | GO:0042308 | negative regulation of protein import into nucleus |
| Biological Process | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0035332 | positive regulation of hippo signaling |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:0070972 | protein localization to endoplasmic reticulum |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0060306 | regulation of membrane repolarization |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
| Biological Process | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| Biological Process | GO:1901379 | regulation of potassium ion transmembrane transport |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.