Overview
| Uniprot ID | P62268 |
|---|
| Protein Name | Small ribosomal subunit protein uS12 |
|---|
| Gene Name | Rps23 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
LVAGFGRKGHAVGDI |
| 135 |
VSLLALYKGKKERPR |
| 21 |
RSHRRDQKWHDKQYK |
| 25 |
RDQKWHDKQYKKAHL |
| 29 |
WHDKQYKKAHLGTAL |
| 37 |
AHLGTALKANPFGGA |
| 48 |
FGGASHAKGIVLEKV |
| 54 |
AKGIVLEKVGVEAKQ |
Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Protein Sequence
10
MGKCRGLRTA
20
RKLRSHRRDQ
30
KWHDKQYKKA
40
HLGTALKANP
50
FGGASHAKGI
60
VLEKVGVEAK
70
QPNSAIRKCV
80
RVQLIKNGKK
90
ITAFVPNDGC
100
LNFIEENDEV
110
LVAGFGRKGH
120
AVGDIPGVRF
130
KVVKVANVSL
140
LALYKGKKER
PRS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098556 |
cytoplasmic side of rough endoplasmic reticulum membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0022626 |
cytosolic ribosome |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0005840 |
ribosome |
| Cellular Component |
GO:0015935 |
small ribosomal subunit |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Molecular Function |
GO:0045182 |
translation regulator activity |
| Biological Process |
GO:0002181 |
cytoplasmic translation |
| Biological Process |
GO:1990145 |
maintenance of translational fidelity |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0034063 |
stress granule assembly |
| Biological Process |
GO:0006412 |
translation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.